产品名称

CBL抗体

英文名称

CBL

产品规格

50ul  100ul 200ul 

产品货号

GOY-01K2750

产品分类

抗体 / 一抗

交叉反应

Human, Mouse, Rat

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

标记

Unconjugated

抗体来源

Rabbit

抗体类型

Monoclonal 

研究领域

肿瘤 细胞生物 **学 信号转导

蛋白细胞定位

细胞膜

纯化方法

affinity purified by Protein A

性状

Liquid

浓度

1mg/ml

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

发货地

上海

背景资料

This e is a proto-oncoe that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This e has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this e are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]