产品名称

Phospho-PLCG1 (Ser1248)抗体

英文名称

Phospho-PLCG1 (Ser1248)

产品规格

50ul  100ul 200ul 

产品货号

GOY-01K2721

产品分类

抗体 / 一抗

交叉反应

Human, Mouse, Rat, Dog, Pig, Cow, Horse

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

标记

Unconjugated

抗体来源

Rabbit

抗体类型

Monoclonal 

研究领域

肿瘤 **学 信号转导 转录调节因子 激酶和磷酸酶

蛋白细胞定位

细胞核,细胞浆

纯化方法

affinity purified by Protein A

性状

Liquid

浓度

1mg/ml

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

发货地

上海

背景资料

The protein encoded by this e catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this e. [provided by RefSeq, Jul 2008].