产品名称

Phospho-PDGF Receptor beta (Tyr740)抗体

英文名称

Phospho-PDGF Receptor beta (Tyr740)

产品规格

50ul  100ul 200ul 

产品货号

GOY-01K2720

产品分类

抗体 / 一抗

交叉反应

Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

标记

Unconjugated

抗体来源

Rabbit

抗体类型

Monoclonal 

研究领域

肿瘤 细胞生物 信号转导 细胞凋亡 生长因子和** 细胞膜受体

蛋白细胞定位

细胞膜

纯化方法

affinity purified by Protein A

性状

Liquid

浓度

1mg/ml

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

发货地

上海

背景资料

The PDGF Receptor Type A (Alpha platelet-derived growth factor receptor precursor, CD140a anti), a 170kD protein, binds all three isoforms of PDGF with high affinity whereas the PDGF Receptor Type B, a 190kD protein, appears to bind only the PDGF BB homodimer with high affinity. Both receptors are transmembranous, ligand activated protein tyrosine kinases, which phosphorylate a number of important signal transduction proteins, which are bound with differential affinities via SH2 domains. The response of any given cell to PDGF will depend on the types of receptors displayed on the surface and isoforms of PDGF present in the extracellular environment.