商品属性:
产品名称
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phospho-CBL (Tyr731)抗体
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英文名称
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phospho-CBL (Tyr731)
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产品规格
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50ul 100ul 200ul
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产品货号
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GOY-01K2708
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产品分类
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抗体 / 一抗
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交叉反应
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Human, Mouse, Rat, Dog, Pig, Cow
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保存条件
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Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
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标记
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Unconjugated
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抗体来源
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Rabbit
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抗体类型
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Monoclonal
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研究领域
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肿瘤 细胞生物 **学 信号转导
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蛋白细胞定位
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细胞膜
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纯化方法
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affinity purified by Protein A
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性状
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Liquid
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浓度
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1mg/ml
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储存液
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0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
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发货地
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上海
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背景资料
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This e is a proto-oncoe that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This e has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this e are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
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