产品名称

Simian Rotavirus VP8抗体

英文名称

Simian Rotavirus VP8

产品规格

50ul  100ul 200ul 

产品货号

GOY-01K2602

产品分类

抗体 / 一抗

交叉反应

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

标记

Unconjugated

抗体来源

Rabbit

抗体类型

Monoclonal 

研究领域

细胞生物 **及病毒

蛋白细胞定位

纯化方法

Affinity purified by Protein A

性状

Liquid

浓度

1mg/ml

储存液

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

发货地

上海

背景资料

Simian Rotavirus VP4 (Outer Capsid protein VP4) (Hemagglutinin) functions as a spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1. VP4 is a homotrimer and adopts a dimeric appearance above the capsid surface, while forming a trimeric base anchored inside the capsid layer. The priming trypsin cleavage triggers its rearrangement into rigid spikes with approximate two-fold symmetry of their protruding parts. After an unknown second triggering event,