产品名称

SCAP2抗体

英文名称

SCAP2

产品规格

50ul  100ul 200ul 

产品货号

GOY-01K1733

产品分类

抗体 / 一抗

交叉反应

Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep

保存条件

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

标记

Unconjugated

抗体来源

Rabbit

抗体类型

Polyclonal

研究领域

细胞生物 信号转导 激酶和磷酸酶 **细胞

蛋白细胞定位

细胞浆

纯化方法

affinity purified by Protein A

性状

Liquid

浓度

1mg/ml

储存液

 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

发货地

上海

背景资料

Fyb (Fyn binding protein) and the anchoring proteins SKAP55 and SKAP55-R (SKAP55-related protein) associate with the tyrosine kinase p59fyn. SKAP55 and SKAP55-R bind to Fyb through their SH3 domains and function as substrates for p59Fyn in resting T cells. SKAP55 contains an N-terminal pleckstrin homology domain and a C-terminal SH3 domain binding motif of adjacent arginine and lysine residues followed by tandem tyrosines (i.e. RKxxYxxY). SKAP55-R, similar in overall structure to SKAP55, contains a coiled-coil N-terminal domain. SKAP55 associates with SLAP-130, another component of the Fyn complex, which plays a role in the regulation of signaling events initiated by lymphocyte anti receptors leading up to T cell activation. The human SKAP55 e maps to chromosome 17q21.32 and encodes a 359 amino acid protein.