性能参数
产品名称
IOX2(Glycine)
规格
10mM (in 1mL DMSO) 10mg 50mg
货号
GOY-Y3992
含量
>98.00%
CAS
931398-72-0
别名
化学名
2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid
分子式
C19H16N2O5
分子量
分子量 352.34
溶解度
≥ 17.6 mg/mL in DMSO
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
IOX2 is a potent and selective inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with an IC50 of 21 nM for PHD2/ELGN-1 in a cell-free assay, IOX2 has shown >100-fold selectivity over JMJD2A, JMJD2C, JMJD2E, JMJD3, or the 2OG oxygenase FIH [1].
PHDs consist three isoforms, named PHD1, PHD2 and PHD3. PHDs are dioxygenases that utilize oxygen as co-substrate providing the molecular basis for the oxygen-sensing function of these enzymes. It has been reported that PHDs are strikingly sensitive to graded levels of hypoxia, mirroring the progressive increases in HIF-1α protein and DNA binding activity that are observed when cells are exposed to gradual hypoxia [2]. In RCC4 cells, IOX2 inhibited HIF-1α hydroxylation at 50 μM [1].
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