性能参数

产品名称

CARM1-IN-1 hydrochloride

规格

10mM*1mLinDMSO 5mg 10mg 50mg

货号

GOY-Y3673

 含量

>98.00%

CAS

N/A

别名

N/A

化学名

N/A

分子式

C26H22Br2ClNO3

分子量

分子量 591.72

溶解度

DMSO : ≥ 38 mg/mL (64.22 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

CARM1-IN-1 hydrochloride is a potent and specific CARM1(Coactivator-associated arginine methyltransferase 1) inhibitor with IC50 of 8.6 uM; shows very low activity against PRMT1 and SET7(IC50 > 600 uM). IC50 value: 8.6 uM [1]Target: CRAM1 inhibitorin vitro: CARM1-IN-1 displays high and selective CARM1 inhibition, with lower or no activity against a panel of different PRMTs or HKMTs. In human LNCaP cells, CARM1-IN-1 shows a significant dose-dependent reduction of the PSA promoter activity.

[1]. Cheng D, et al. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54(13):4928-32.

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异戊酸甲酯  556-24-1  三氯化钛  2120424

N-乙酰-L-硫代脯氨酸  54323-50-1  2-溴-5-甲基三氟甲苯  261952-20-9

5-苯基吡啶甲酸  75754-04-0  3,4-二氯苯氧基乙酸  588-22-7

2,4,5-三氟苯酚  2268-16-8  2-乙炔基苯甲醛  38846-64-9

戊烯二酸  1724-02-3  2-氟-5-氨基吡啶  1827-27-6

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