性能参数 |
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产品名称 |
BRD4 degrader AT1 |
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规格 |
5mg 10mg 25mg 50mg |
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货号 |
GOY-Y3667 |
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含量 |
>98.00% |
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CAS |
2098836-45-2 |
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别名 |
N/A |
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化学名 |
N/A |
分子式 |
C48H58ClN9O5S3 |
分子量 |
分子量 972.68 |
溶解度 |
DMSO : 100 mg/mL (102.81 mM) |
储存条件 |
Store at -20°C |
General tips |
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用途 |
仅供科研 |
价格 |
电询 |
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详细内容 |
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. BRD4 degrader AT1 is a highly selective Brd4 degrader, with a Kd of 44 nM, for Brd4BD2 in cells. BRD4 degrader AT1 also shows Kds of 38.8 nM for a mutant Brd4BD2 (QVK), 111 ± 14 nM for Brd2BD1, 94 ± 9 nM for Brd2BD2, 35 ± 3 nM for Brd3BD1, 39 ± 8 nM for Brd3BD2, 75 ± 23 nM for Brd4BD1 and 35 ± 4 nM for a Brd2BD1 mutant (KEA). BRD4 degrader AT1 (1-3 μM) causes remarkable Brd4-selective depletion and has no or little activity against Brd2 and Brd3[1]. [1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521. |
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