性能参数

产品名称

Enarodustat

规格

250mg 500mg

货号

GOY-Y3572

 含量

>98.00%

CAS

1262132-81-9

别名

N/A

化学名

N/A

分子式

C17H16N4O4

分子量

分子量 340.33

溶解度

DMSO: 83.33 mg/mL (244.85 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Enarodustat is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM; Enarodustat has entered clinical trial for renal anemia.

Enarodustat (JTZ-951) is a potent and orally active factor prolyl hydroxylase inhibitor, with an EC50 of 0.22 μM. Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition[1].

Enarodustat (1 and 3 mg/kg, p.o.) increases hemoglobin levels in a dose-dependent manner with daily oral dosing in rats[1].

[1]. Ogoshi Y, et al. Discovery of JTZ-951: A HIF Prolyl Hydroxylase Inhibitor for the Treatment of Renal Anemia. ACS Med Chem Lett. 2017 Nov 20;8(12):1320-1325.

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