性能参数

产品名称

Abrocitinib (PF-04965842)

规格

10mM*1mLinDMSO 5mg 10mg

货号

GOY-Y3540

 含量

>98.00%

CAS

1622902-68-4

别名

N/A

化学名

N/A

分子式

C14H21N5O2S

分子量

分子量 323.41

溶解度

DMSO : 125 mg/mL (386.51 mM)

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Abrocitinib (PF-04965842) is a potent, oral active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1,STAT3 and STAT5 after stimulation. Effective in autoimmune disease[1].

Abrocitinib (Compound 25) inhibits IFNα-stimulated phosphorylation of STAT3, IFN-stimulated phosphorylation of STAT1 in human whole blood (HWB), as well as pSTAT5 in CD34+ spiked into HWB (JAK2), with IC50s of 189, 163 nM, 7.178 μM, respectively[1].

[1]. Vazquez ML, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152.

3-溴呋喃  22037-28-1  1-氨基环丙烷羧酸  22059-21-8

乙基乙酰亚胺盐酸盐  112680  1,3-二溴-2,2-二甲氧基丙烷  22094-18-4

2-氰基溴苄  22115-41-9  2,3-二氯喹喔啉  2213-63-0

4-苯氧基苯甲酸  2215-77-2  L-(+)-酒石酸二异丙酯  2217-15-4

2-羟基-3-三氟甲基吡啶  22245-83-6  6-氯-2-甲基-3-硝基吡啶  22280-60-0

4-溴-2-甲基吡啶  22282-99-1 default-locale

3-甲硫基丁醛3-(Methylthio)butanal,≥96%16630-52-710G

反,反-2,4-庚二烯醛2,4-Heptadienal,90%8813951G

2-溴-3-吡啶甲醛2-Bromo-3-pyridinecarboxaldehyde,97%128071-75-01G

2-氯-3-吡啶甲醛2-Chloro-3-pyridinecarboxaldehyde,97%36404-88-31G

6-甲基-2-吡啶醛6-Methylpyridine-2-carboxaldehyde,98%1122-72-11G

6-甲氧基-3-吡啶甲醛6-Methoxy-3-pyridinecarboxaldehyde,98%65873-72-51G