(S)-PFI-2 (hydrochloride)
如果您对该产品感兴趣的话,可以
产品名称:
(S)-PFI-2 (hydrochloride)
产品型号:
GOY-Y3537
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-08
简单介绍
(S)-PFI-2 (hydrochloride)≤0.5mg/ml in ethanol;2mg/ml in DMSO;5mg/ml in dimethyl formamide
(S)-PFI-2 (hydrochloride)
的详细介绍
性能参数
|
产品名称
|
(S)-PFI-2 (hydrochloride)
|
规格
|
1mg 5mg 10mg
|
货号
|
GOY-Y3537
|
含量
|
>98.00%
|
CAS
|
1627607-88-8
|
别名
|
(+)-PFI-2
|
|
|
化学名
|
8-fluoro-1,2,3,4-tetrahydro-N-[(1S)-2-oxo-2-(1-pyrrolidinyl)-1-[[3-(trifluoromethyl)phenyl]methyl]ethyl]-6-isoquinolinesulfonamide, monohydrochloride
|
分子式
|
C23H25F4N3O3S ? HCl
|
分子量
|
分子量 536.0
|
溶解度
|
≤0.5mg/ml in ethanol;2mg/ml in DMSO;5mg/ml in dimethyl formamide
|
储存条件
|
Store at -20°C
|
General tips
|
|
用途
|
仅供科研
|
价格
|
电询
|
|
详细内容
|
(S)-PFI-2 (hydrochloride) is the inactive enantiomer of (R)-PFI-2 and may serve as a negative control. (R)-PFI-2 is a cell-permeable and potent SET7/9 inhibitor with IC50 value of 2 nM [1].
Protein methyltransferases involve in the epigenetic regulation of gene transcription, silencing, chromatin structure establishment, maintenance, DNA repair, and replication. SET domain containing (lysine methyltransferase) 7 (SETD7) (SET9; SET7/9, KMT7) is a protein lysine methyltransferases and is originally characterized as a monomethyltransferase of lysine 4 on histone H3 (H3K4me1). SET7/9 has very broad target specificity that methylates histone H3, tumor suppressor p53 and transcription factor TAF10 [1][2][3].
(S)-PFI-2 (hydrochloride), the inactive enantiomer of (R)-PFI-2, was 500-fold less potent with IC50 value of 1 μM and used as a negative control in chemical biology experiments. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase with IC50 value of 2 nM. In high-density MCF7 cells, (R)-PFI-2 dose-dependently increased nuclear YAP and enhanced expression of the YAP target genes AREG and CYR61, whereas (S)-PFI-2 had no effect [1].
|
公司正在销售的产品:
2-溴-2-甲基丙酰溴 20769-85-1 2-氨基-4-溴苯甲酸 20776-50-5
4-溴吲哚满二酮 20780-72-7 2,4-二甲氧基苯甲胺 20781-20-8
L-叔亮氨酸 20859-02-3 5-氨基-1,3-二氢吲哚-2-酮 20876-36-2
2-氰基-3-甲基吡啶 20970-75-6 5-溴烟酸乙酯 20986-40-7
L-苯甘氨醇 20989-17-7 2,4,5-三氟硝基苯 2105-61-5
4-溴-2-氟苯酚 2105-94-4 ?
|
SAR5022505 mg 10 mg 25 mg 50 mg 100 mg>99.50%Cas No. 503860-57-9C19H18FN5O2
SAG hydrochloride1mg 5mg 10mg 25mg 50mg>99.50%Cas No. 2095432-58-7C28H29Cl2N3OS
Teplinovivint5 mg 10 mg 25 mg 50 mg 100 mg>99.50%Cas No. 1428064-91-8C25H26N6O2
XMU-MP-12mg 5mg 10mg 25mg 100mg>99.00%Cas No. 2061980-01-4C17H16N6O3S2
|