性能参数

产品名称

Resminostat hydrochloride

规格

mg 50mg

货号

GOY-Y3531

 含量

>98.00%

CAS

1187075-34-8

别名

RAS2410 hydrochloride;4SC-201 hydrochloride;RAS 2410 hydrochloride;RAS-2410 hydrochloride

化学名

(Z)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide hydrochloride

分子式

C16H20ClN3O4S

分子量

分子量 385.87

溶解度

DMF: 0.5 mg/ml,DMSO: 10 mg/ml,PBS (pH 7.2): 0.5 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Resminostat is an inhibitor of histone deacetylase (HDAC) with IC50 values of 42.5nM, 50.1nM and 71.8nM, respectively against HDAC1, 3 and 6 [1].

As an inhibitor of HDACs, resminostat also inhibits HDAC8 with a weak activity (IC50=877nM). 5μM resminostat induces the acetylation of histone H4 in U266 myeloma cells. 10μM resminostat completely suppresses the cell growth in human myeloma cell lines, such as OPM-2, RPMI-8226 and U266. This inhibition is proved to be caused by the induction of apoptosis. In primary myeloma cells, resminostat also induces apoptosis of cells. Besides that, resminostat is proved to downregulate the expression of cell cycle proteins, including phosphorylated Rb, cdc25a, cyclin D1, Cdk4 and p53. In addition, resminostat is reported to be well tolerated, have no unexpected toxicities and do not cause clinically significant myelosuppression in the first-human study [1, 2].

4-甲苯磺酰氰  19158-51-1  劳森试剂  19172-47-5

3,5-二甲氧基苯硼酸  192182-54-0  3-氯-4-氟溴苄  192702-01-5

DL-高丝氨酸  1927-25-9  3-(4-甲氧基苯基)丙酸  1929-29-9

1-叔丁氧羰基-3-胺基环丁胺  193269-78-2  二氰胺钠  1934-75-4

肼甲酰亚胺酰胺一氯化氢  1937-19-5  苄磺酰氯  1939-99-7

3-羟基苯甲酸甲酯  19438-10-9  2-苯乙基异氰酸酯  194?

C345mg 10mg 25mg 50mg>98.00%Cas No. 40592-88-9C17H27NO9

BTX1615 mg 10 mg 25 mg 50 mg>98.00%Cas No. 2052301-24-1C15H16N2O3

BRD37315 mg 10 mg 50 mg 100 mg>98.00%Cas No. 2056262-07-6C24H31N3O

BRD-K44775 mg 10 mg 25 mg 50 mg>98.00%Cas No. 2719-05-3C17H18N2O2

BODIPY-aminoacetaldehyde diethyl acetal50 μg 100 μg 500 μg 1 mg>95.00%Cas No. 247069-93-8C20H28BF2N3O3

AY 9944 dihydrochloride1mg 5mg 10mg 25mg>99.50%Cas No. 366-93-8C22H28Cl2N2.2HCl

ALLO-25mg 10mg 50mg 100mg>99.50%Cas No. 1357350-60-7C18H12F3N5O