性能参数
产品名称
Dot1L-IN-2
规格
250mg 500mg
货号
GOY-Y3490
含量
>98.00%
CAS
1940206-71-2
别名
N/A
化学名
分子式
C27H24N8O
分子量
分子量 476.53
溶解度
Soluble in DMSO
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Dot1L-IN-2 is a potent, selective and orally bioavailable inhibitor of Dot1L (a histone methyltransferase), with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively.
Dot1L-IN-2 is a potent, selective Dot1L inhibitor, with an IC50 and Ki of 0.4 nM and 0.08 nM, respectively. Dot1L-IN-2 potently inhibits H3K79 dimethylation (IC50, 16 nM), and blocks the activity of the HoxA9 promoter (IC50, 340 nM) in cellular systems. Dot1L-IN-2 also dramatically suppresses proliferation of the human MLL-rearranged leukemia cell line MV4-11 carrying the oncogenic MLL-AF4 fusion (IC50, 128 nM)[1].
[1]. Chen C, et al. Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach. ACS Med Chem Lett. 2016 Jun 1;7(8):735-40.
公司正在销售的产品:
2,6-二叔丁基苯酚 128-39-2 羟丙基-BETA-环糊精 128446-35-5
N-乙基马来酰亚胺 128-53-0 1H-苯并三唑-1-基氧三吡咯烷基六氟磷酸盐[用于肽的偶联剂] 128625-52-5
1--BOC-3-哌嗪甲酸甲酯 129799-08-2 5-氯-2,4-二氟苯甲酸 130025-33-1
3-氯丙基异氰酸酯 13010-19-0 氧化铝 1302-74-5
N-Cbz-3-吡咯烷酮 130312-02-6 三氧化二硼 1303-86-2
硼砂?
Halometasone1 mg 5 mg 10 mg 25 mg>98.00%Cas No. 50629-82-8C22H27ClF2O5
Goserelin acetate10mM*1mL in DMSO 5mg 10mg 50mg>99.00%Cas No. 145781-92-6C61H88N18O16
Gluten Exorphin C1mg 5mg 10mg 25mg>98.50%Cas No. 142479-62-7C29H45N5O8
Glucocorticoid Resistance Inhibitor1mg 5mg 10mg 25mg>98.00%Cas No. 947018-15-7C12H12N4
GLPG0492 R enantiomer2mg 5mg 10mg 50mg>99.50%Cas No. 1215085-93-0C19H14F3N3O3
传真号码:021-39596320 021-39921927
QQ: 3004918891 3004905818 3004901493 移动电话:18321818584 15026555973 地址:上海松江新砖公路1155号
产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!