性能参数
产品名称
Acriflavine
规格
100mg
货号
GOY-Y3428
含量
>98.00%
CAS
8048-52-0
别名
N/A
化学名
分子式
C14H14ClN3
分子量
分子量 259.73
溶解度
H2O : ≥ 25 mg/mL (96.25 mM)
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Acriflavine is a fluorescent dye for labeling high molecular weight RNA. It is also a topical antiseptic.
Acriflavine is identified as a potent inhibitor of the MCT4 that can inhibit the binding between Basigin and MCT4. Acriflavine significantly inhibits growth and self-renewal potential of several glioblastoma neurosphere lines[1]. The HIF-1 inhibitor acriflavine decreases survival and growth of CML cells. It targets stem cell potential of CML cells[2].
Acriflavine treatment inhibits intratumoral expression of VEGF and tumor vascularization[1]. In a murine CML model, acriflavine decreases leukemia development and reduces LSC maintenance[2]. Acriflavine retards tumor growth in a murine model of breast cancer. The combination of sunitinib with acriflavine significantly decreases vascular endothelial growth factor and TGF-β expression and reduces tumor vasculature followed by increased intratumor necrosis and apoptosis[3].
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!