性能参数

产品名称

proTAME

规格

1mg

货号

GOY-Y3399

 含量

>90.00%

CAS

1362911-19-0

别名

N/A

化学名

N/A

分子式

C34H38N4O12S

分子量

分子量 726.8

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

proTAME is a cell-permeable prodrug form of N-4-tosyl-L-arginine methyl ester , an inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that is converted to TAME by intracellular esterases. proTAME (12 μM) blocks association of APC/C with the activator CDH1 and inhibits degradation of APC/C substrates in HeLa cells. It induces mitotic arrest in metaphase followed by cell death in synchronized HeLa H2B-GFP cells when used at a concentration of 12 μM. It also increases mitotic duration in asynchronous HeLa H2B-GFP cells at a concentration of 4 μM, an effect that is enhanced by knockdown of the APC/C co-activator CDC20. proTAME decreases the viability of several laboratory and primary patient-derived human multiple myeloma (MM) cell lines (IC50s = 2.8-20.3 μM) and increases apoptosis in RPMI-8226, LP-1, NCI-H929, and U266 MM cells when used at a concentration of 12 μM.

1,4-二氯苯  106-46-7  对苯二胺  106-50-3

N-羟基琥珀酰亚胺磺酸钠盐  106627-54-7  膦?；宜峒柞ザ阴? 1067-74-9

异丙基氯化镁  1068-55-9  甲基丙烯酸缩水甘油酯  106-91-2

阿德福韦  106941-25-7  2-羟基吡啶-5-醛  106984-91-2

1-氨基环丙甲醇  107017-72-1  丙烯醛  107-02-8

丙烯酰氯  107-05-1  烯丙胺  107-11-9

1β-Acetoxypolygodial1mg 5mg>95.00%Cas No. 1818425-44-3C17H24O4

17-hydroxy Venturicidin A500μg 1mg>95.00%Cas No. 113204-43-6C41H67NO12

2-O-(α-D-Glucopyranosyl)glycerol1 g 5 g>95.00%Cas No. 22160-26-5C9H18O8

2-heptyl-3-hydroxy-4(1H)-Quinolone5mg 10mg>95.00%Cas No. 108985-27-9C16H21NO2

19,20-Epoxycytochalasin C1mg 5mg>95.00%Cas No. 189351-79-9C30H37NO7

4-(N-Boc-amino)piperidine1 g 5 g>95.00%Cas No. 73874-95-0C10H20N2O2

3-hydroxy Docosanoic Acid500μg 1mg>95.00%Cas No. 89946-08-7C22H44O3