PROTAC RIPK degrader-6
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产品名称:
PROTAC RIPK degrader-6
产品型号:
GOY-Y3325
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-05
简单介绍
PROTAC RIPK degrader-6DMSO: 100 mg/mL (112.49 mM)
PROTAC RIPK degrader-6
的详细介绍
性能参数
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产品名称
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PROTAC RIPK degrader-6
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规格
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10mM*1 mL in DMSO 5mg 10mg 25mg
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货号
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GOY-Y3325
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含量
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>99.00%
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CAS
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2089205-64-9
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别名
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N/A
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化学名
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N/A
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分子式
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C43H48N6O11S2
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分子量
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分子量 889
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溶解度
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DMSO: 100 mg/mL (112.49 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder[1].
PROTACs is useful for the targeted degradation of proteins and other polypeptides which on the one end binds to the cereblon and on the other end to the target protein (RIP2 kinase). By bringing the target protein in close proximity to the E3-Ligase, these compounds form a ternary complex leading to polyubiquitination of the target protein inducing its degradation[1].
[1]. John David Harlin, et al. Compounds for the modulation of rip2 kinase activity. WO2017046036A1
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