性能参数

产品名称

Nelarabine

规格

10mM (in 1mL DMSO) 5mg 25mg 100mg

货号

GOY-Y3225

 含量

>98.00%

CAS

121032-29-9

别名

化学名

(2R,3S,4S,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

分子式

C11H15N5O5

分子量

分子量 297.27

溶解度

≥ 14.85mg/mL in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nelarabine is a novel and prodrug of ara-G (9-β-d-arabinofuranosylguanine), and it is used to treat T-cell lymphoblastic lymphoma (T-LBL) and T-cell acute lymphoblastic leukemia (T-ALL), which don’t have response after treatment with 2 chemotherapy regimens.[1]

It acts as an inhibitor by inhibiting DNA synthesis and as an inducer by inducing apoptosis in malignant cells. Nelarabine requires demethylation by adenosine deaminase (ADA) in plasma to form the active compound, ara-G. Intracellular by deoxyguanosine kinase and deoxycytidine kinase phosphorylate ara-G to its triphosphate form, ara-GTP. Inside the cell exposure to ara-GTP is much higher than the exposure to ara-G or nelarabine. The substitution of ara-GTP for GTP leads to inhibition of DNA synthesis resulting in cell death by apoptosis. This process is lethal to malignant T cells, as it is to other rapidly replicating cells.[2]

6-甲氧基烟酸甲酯  26218-80-4  三环己基膦  2622-14-2

2-碘苯甲醛  26260-02-6  乙醛酸薄荷酯  26315-61-7

alpha-溴-4-甲氧基苯乙酮  2632-13-5  2-疏基吡啶  2637-34-5

4,4'-偶氮双(4-氰基戊酸)  2638-94-0  H-ORN(CBZ)-OH  2640-58-6

2,5-二氟苯甲醛  2646-90-4  甲基环戊二烯二聚体  26472-00-4

N-苄氧羰基-L-谷氨酰胺  2650-64-8  3-硝基吡?

Metoclopramide (hydrochloride)10g 25g 50g 100g>98.00%Cas No. 7232-21-5C14H22ClN3O2?HCl

MHP 1331mg 5mg 10mg 20mg>98.00%Cas No. 147340-43-0C17H20ClN5O3

Myelin Basic Protein (87-99)1mg 5mg 10mg 25mg>98.00%Cas No. 118506-26-6C74H114N20O17

Mofegiline hydrochloride50mg 100mg 200mg 500mg>98.00%Cas No. 120635-25-8C11H14ClF2N

MLS-15471mg 5mg 10mg 25mg>98.00%Cas No. 315698-36-3C19H19ClN4O

ML 2891mg 5mg 10mg 25mg>98.00%Cas No. 1382481-79-9C22H23NO3

N-Decanoyl p-Nitroaniline5mg 10mg 25mg 50mg>98.00%Cas No. 72298-63-6C16H24N2O3