性能参数
产品名称
Plumbagin
规格
10mM (in 1mL DMSO) 5 mg 25 mg
货号
GOY-Y3196
含量
>98.00%
CAS
481-42-5
别名
化学名
5-hydroxy-2-methylnaphthalene-1,4-dione
分子式
C11H8O3
分子量
分子量 188.18
溶解度
≥ 6.35mg/mL in DMSO, ≥ 25.75 mg/mL in EtOH with ultrasonic
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
IC50: 11.69 μM for A549 cells
Plumbagin, a quinonoid constituent isolated from the root of Plumbago zeylanica L., has been shown to exert anticarcinogenic, antiatherosclerotic, and antimicrobial effects.
In vitro: Plumbagin exhibited effective cell growth inhibition via inducing cancer cells to undergo G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased levels of p21 and reduced amounts of Cdc2, Cdc25C and cyclinB1. Plumbagin treatment also found to enhance the levels of inactivated phosphorylated Cdc2 and Cdc25C. Blockade of p53 activity partially decreased plumbagin-induced apoptosis and G2/M arrest, indicating it might be operated by p53-dependent and independent pathway [1].
In vivo: To determine whether plumbagin inhibited the in vivo tumor growth, A549 cells were injected into nude mice. Tumor growth inhibition was most evident in mice treated with plumbagin at 2 mg/kg/day, where around 80% reductions in tumor size were observed, in contrast with mice treated with the vehicle. No sign of toxicity was observed in plumbagin-treated mice as judged by monitoring body weight [1].
Clinical trial: N/A
公司正在销售的产品:
2-溴-6-三氟甲基吡啶 189278-27-1 1-Boc-4-甲基-4-哌甲酸 189321-63-9
BOC-D-苯丙氨酸 18942-49-9 3-氟--5-甲基苯甲醛 189628-39-5
2-溴苄醇 18982-54-2 A,A二苯基Β苦基肼基游离基 1898-66-4
无水柠檬酸单钠盐 18996-35-5 N-甲基-3-氨基吡唑 1904-31-0
2,6-二氨基嘌呤 1904-98-9 4-溴-3-甲氧基苯胺 19056-40-7
3-溴-4-甲氧基苯胺?
MFZ 10-710mg 50mg>98.00%Cas No. 1224431-15-5C15H9FN2.HCl
Mianserin5mg 100mg>98.00%Cas No. 24219-97-4C18H20N2
Mirtazapine D31mg 5mg>98.00%Cas No. 1216678-68-0C17H16D3N3
Methyl Salicylate (Wintergreen oil)10mM*1mLinDMSO 50mg>98.00%Cas No. 119-36-8C8H8O3
Methiothepin mesylate (Metitepine mesylate)10mM*1mLinDMSO 10mg>98.00%Cas No. 74611-28-2C21H28N2O3S3
Methimepip dihydrobromide10mg 50mg>98.00%Cas No. 817636-54-7C10H17N3.2HBr
Methacholine chloride (Acetyl-β-methylcholine chloride)10mM*1mLinDMSO 100mg>98.00%Cas No. 62-51-1C8H18ClNO2
传真号码:021-39596320 021-39921927
QQ: 3004918891 3004905818 3004901493 移动电话:18321818584 15026555973 地址:上海松江新砖公路1155号
产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!