Rasagiline Mesylate
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产品名称:
Rasagiline Mesylate
产品型号:
GOY-Y3147
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-05
简单介绍
Rasagiline Mesylate≥ 13.4 mg/mL in DMSO, ≥ 46 mg/mL in EtOH with ultrasonic, ≥ 95.8 mg/mL in H2O
Rasagiline Mesylate
的详细介绍
性能参数
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产品名称
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Rasagiline Mesylate
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规格
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10mM (in 1mL DMSO) 50mg
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货号
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GOY-Y3147
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含量
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>98.00%
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CAS
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161735-79-1
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别名
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化学名
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methanesulfonic acid;(1R)-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
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分子式
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C12H13N.CH4O3S
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分子量
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分子量 267.34
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溶解度
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≥ 13.4 mg/mL in DMSO, ≥ 46 mg/mL in EtOH with ultrasonic, ≥ 95.8 mg/mL in H2O
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Rasagiline mesylate is a new MAO-B inhibitor for the treatment of idiopathic Parkinson's disease. Target: Monoamine Oxidase (MAO)-BRasagiline (N-propargyl-1-(R)-aminoindan) is a novel, highly potent irreversible monoamine oxidase (MAO)-B inhibitor, anti-Parkinsonian drug. Rasagiline is effective as monotherapy or adjunct to L-Dopa for patients with early and late Parkinson's disease (PD) [1]. Rasagiline inhibits MAO-B more potently than selegiline and has the advantage of once-daily dosing. In several large, randomized, placebo-controlled trials, rasagiline has demonstrated efficacy as monotherapy in early PD and as adjunctive therapy in advanced PD. In addition, rasagiline has been shown to have neuroprotective effects in in vitro and in vivo studies. The recently completed delayed-start ADAGIO (Attenuation of Disease Progression with Azilect Given Once-daily) trial suggests a potential disease-modifying effect for rasagiline 1 mg/day, though the clinical import of this finding has yet to be established [2]. Rasagiline has been found to be well tolerated and effective in the treatment of early PD and as adjunctive treatment in motor fluctuations. Whether rasagiline is associated with clinically significant neuroprotection (ie, disease modification) in PD is the subject of ongoing clinical trials [3].
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