性能参数
产品名称
Osthole
规格
10mM (in 1mL DMSO) 500mg
货号
GOY-Y3135
含量
>98.00%
CAS
484-12-8
别名
化学名
7-methoxy-8-(3-methylbut-2-enyl)chromen-2-one
分子式
C15H16O3
分子量
分子量 244.29
溶解度
≥ 10.3mg/mL in DMSO
储存条件
General tips
用途
仅供科研
价格
电询
详细内容
Osthole is a natural antihistamine alternative. Osthole may be a potential inhibitor of histamine H1 receptor activity.
Osthole (pcol1), bone sialoprotein (BSP) and osteocalcin (OC) (2 days of culture). Osthole promotes ALP activity in mouse primary osteoblasts in a dose-dependent manner[2].
Subcutaneous injection of Osthole at a dose of 5 mg/kg per day onto mouse calvariae significantly stimulates local bone formation, as shown by histologic analysis of calvarial samples harvested 2 weeks after the last injection and stained with H&E orange G. Histomorphometric analysis reveals that Osthole has a significant effect on bone formation as potent as the positive control, the microtubule inhibitor TN-16. This effect, however, is not seen when Osthole is used at a dose of 1 mg/kg per day. Intraperitoneal injection of Osthole for 8 weeks significantly reverses bone loss in the ovariectomized rats. Histologic examination of the L4samples stained with trinitrophenol poinsettia demonstrates a partial recovery of the trabecular structure in ovariectomized rats treated with Osthole. Histomorphometric analysis shows that treatment with Osthole significantly increases total BMD, trabecular bone volume, and trabecular thickness and decreases trabecular separation[2].
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!