性能参数
产品名称
Nebivolol
规格
10mM (in 1mL DMSO) 10mg
货号
GOY-Y3129
含量
>98.00%
CAS
152520-56-4
别名
化学名
(1S)-1-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2S)-2-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol;hydrochloride
分子式
C22H26ClF2NO4
分子量
分子量 441.9
溶解度
≥ 22.1mg/mL in DMSO
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Nebivolol hydrochloride selectively inhibits β1- adrenergic receptor with IC50 of 0.8 nM.Target: β1- adrenergic receptorNebivolol reduces cell proliferation of human coronary smooth muscle cells (haCSMCs) and endothelial cells (haECs) in a concentration- and time-dependent maner. Nebivolol treatment for 7 days causes significant reduction in cell growth of haCSMCs with IC50 of 6.1 μM, and inhibits accelerated haCSMC proliferation stimulated by growth factors PDGF-BB, bFGF, and TGFβ with IC50 values of 6.8 μM, 6.4 μM and 7.7 μM, repectively. Nebivolol treatment (10-5 M) of haCSMCs for 48 hours induces a moderate apoptosis of 23% and a decrease from 16% to 5% in the number of cells in S-phase. During Nebivolol incubation, NO formation of HaCEs increases, while endothelin-1 transcription and secretion are suppressed.Administratiion of Nebivolol (initially by iv within 10 minutes of reperfusion and then orally) to rats with myocardial infarction (MI) reduces myocardial apoptosis, which is mediated by regulation of NO . Nebivolol, significantly, prevents left ventricular (LV) pressure changes, reduces total and regional apoptotic cardiomyocytes. Nebivolol treatment lowers mean blood pressure (MBP) in rats with MI slightly, but not significantly.
公司正在销售的产品:
Pentanoic Acid-d9 分子量 111.250mg 100mg 250mg 500mg >98.00% Cas No. 115871-50-6 C5HD9O2
Palmitoyl glutamic acid 分子量 385.545 mg 10 mg 25 mg 50 mg >98.00% Cas No. 38079-66-2 C21H39NO5
OSBPL7-IN-1 分子量 463.285 mg 10 mg 25 mg 50 mg >98.00% Cas No. 126
CP 9634510mg 50mg>98.00%Cas No. 132746-60-2C28H32N2O
CP 122721 hydrochloride5 mg 25 mg>98.00%Cas No. 145877-52-7C20H23F3N2O2.2HCl
Conessine10mM (in 1mL Ethanol) 50mg>98.00%Cas No. 546-06-5C24H40N2No. 131780-48-8C17H21N3O3.HCl
D-AP410mg 50mg>98.00%Cas No. 78739-01-2C4H10NO5P
Cyanopindolol hemifumarate10mg 50mg>98.00%Cas No. 106469-57-2C16H21N3O2.?C4H4O4
传真号码:021-39596320 021-39921927
QQ: 3004918891 3004905818 3004901493 移动电话:18321818584 15026555973 地址:上海松江新砖公路1155号
产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!