PND-1186 hydrochloride
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产品名称:
PND-1186 hydrochloride
产品型号:
GOY-Y3022
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
PND-1186 hydrochlorideDMSO : 200 mg/mL (371.77 mM; Need ultrasonic)|H2O : 20 mg/mL (37.18 mM; Need ultrasonic)
PND-1186 hydrochloride
的详细介绍
性能参数
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产品名称
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PND-1186 hydrochloride
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规格
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10mM*1 mL in DMSO 5 mg 10 mg 50 mg 100 mg
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货号
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GOY-Y3022
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含量
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>98.00%
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CAS
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1356154-94-3
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别名
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N/A
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化学名
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N/A
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分子式
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C25H27ClF3N5O3
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分子量
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分子量 537.96
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溶解度
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DMSO : 200 mg/mL (371.77 mM; Need ultrasonic)|H2O : 20 mg/mL (37.18 mM; Need ultrasonic)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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PND-1186 hydrochloride (VS-4718 hydrochloride) is a potent, highly-specific and reversible inhibitor of FAK with an IC50 of 1.5 nM. PND-1186 hydrochloride selectively promotes tumor cell apoptosis[1].
PND-1186 has an IC50 of ~100 nM in breast carcinoma cells as determined by anti-phospho-specific immunoblotting to FAK Tyr-397[1]. In murine 4T1 breast carcinoma cells, FAK is important in promoting an invasive and metastatic cell phenotype. Increasing concentrations of PND-1186 (0.1 to 1.0 μM) added to 4T1 cells inhibits FAK Tyr-397 phosphorylation (pY397) and results in elevated levels of total FAK protein within 1 h[1].
PND-1186 (30 mg/kg or 100 mg/kg; subcutaneously; injected subcutaneously in the neck region) inhibits 4T1 subcutaneous tumor growth by induction of apoptosis[1].
[1]. Tanjoni I, et al. PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther. 2010 May 15;9(10):764-77.
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