性能参数
产品名称
PIM447
规格
1mg 5mg 10mg 50mg 100mg
货号
GOY-Y3018
含量
>98.00%
CAS
1210608-43-7
别名
N/A
化学名
分子式
C24H23F3N4O
分子量
分子量 440.46
溶解度
DMSO : 33.33 mg/mL (64.92 mM)
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
PIM447 is novel pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase.target: pan-PIM inhibitor [2] [3]In vitro: PIM447 is cytotoxic for myeloma cells due to cell cycle disruption and induction of apoptosis mediated by a decrease in phospho-Bad (Ser112) and c-Myc levels and the inhibition of mTORC1 pathway. PIM447 also inhibits in vitro osteoclast formation and resorption, downregulates key molecules involved in these processes and partially disrupts the F-actin ring, while increasing osteoblast activity and mineralization.[1]In vivo: PIM447 significantly reduces the tumor burden and preventes tumor-associated bone loss in a disseminated murine model of human myeloma.[1]
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!