性能参数
产品名称
Phenoxodiol
规格
1mg 5mg 10mg 50mg 100mg
货号
GOY-Y3016
含量
>98.00%
CAS
81267-65-4
别名
N/A
化学名
分子式
C15H12O3
分子量
分子量 240.25
溶解度
DMSO: ≥ 100 mg/mL (416.23 mM); H2O: < 0.1 mg/mL (insoluble)
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2]. Caspase, DNA topoisomerase II[1][2].
[1]. Kamsteeg M, et al. Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells. Oncogene. 2003 May 1;22(17):2611-20. [2]. Mahoney S, et al. The effects of phenoxodiol on the cell cycle of prostate cancer cell lines. Cancer Cell Int. 2014 Nov 8;14(1):110.
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