Panobinostat (LBH589)
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产品名称:
Panobinostat (LBH589)
产品型号:
GOY-Y3008
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
Panobinostat (LBH589)≥ 17.47mg/mL in DMSO
Panobinostat (LBH589)
的详细介绍
性能参数
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产品名称
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Panobinostat (LBH589)
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规格
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10mM (in 1mL DMSO) 10mg 50mg 200mg 500mg
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货号
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GOY-Y3008
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含量
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>98.00%
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CAS
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404950-80-7
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别名
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Panobinostat,LBH589,LBH-589, Faridak, NVP-LBH589,
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化学名
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(E)-N-hydroxy-3-[4-[[2-(2-methyl-1H-indol-3-yl)ethylamino]methyl]phenyl]prop-2-enamide
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分子式
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C21H23N3O2
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分子量
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分子量 349.43
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溶解度
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≥ 17.47mg/mL in DMSO
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Panobinostat, as known as LBH589, is a novel and potent hydroxamic acid-based deacetylase inhibitor (DACis)that inhibits a broad spectrum of histone deacetylases (HDACs), including all Classes 1, 2 and 4 HDAC enzymes, at low nanomolar concentrations. According to previous studies, it not only induces apoptosis in multiple myeloma (MM) cells via caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage, but also induces potent cell growth inhibition, cell-cycle arrest, and apoptosis in a time- and dose-dependent manner in both Philadelphia chromosome-negative (Ph-) actue lymphoblastic leukemia (ALL) cells lines (T-cell MOLT-4 and pre-B-cell Reh), which are correlated with induction of histone (H3K9 and H4K8) hyperacetylation, activation of p21 and p27, and suppression of c-Myc.
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