性能参数
产品名称
Voreloxin
规格
10mM (in 1mL DMSO) 5mg 10mg 25mg
货号
GOY-Y2972
含量
>98.00%
CAS
175414-77-4
别名
SNS-595; Vosaroxin; AG 7352
化学名
7-[(3S,4S)-3-methoxy-4-(methylamino)pyrrolidin-1-yl]-4-oxo-1-(1,3-thiazol-2-yl)-1,8-naphthyridine-3-carboxylic acid
分子式
C18H19N5O4S
分子量
分子量 401.44
溶解度
<4.01 mg/mL in DMSO, <2.51 mg/mL in EtOH, <2.49 mg/mL in H2O
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Voreloxin, formerly known as SNS-595 or AG-7352, is a novel naphthyridine analog, which is structurally related to the quinolone antibiotics, a chemical class not previously used for the treatment
of cancer.
In vitro: In vitro studies demonstrated voreloxin has broad anti-proliferative activity in 11 tumor cell lines, with IC50 values ranging from 0.04 to 0.97 μM. Similar activity was observed in vitro in drug-resistant cell lines, including those that overexpress P-glycoprotein [2].
In vivo: After a single intravenous dose, voreloxin concentrations in tumor were correlated with induction of the apoptosis marker caspase-3. Administration of voreloxin at 20 mg/kg weekly inhibited tumor growth (86%). Voreloxin demonstrated strong dose-dependent tumor growth inhibition (63–88%) in 10 of 11 solid tumor xenograft models [2].
Clinical trial: Voreloxin showed an acceptable safety profile with clinical activity in patients with relapsed/refractory solid tumors. The maxmum tolerence dose was schedule-dependent. Voreloxin is now in clinical studies of ovarian cancer and acute myeloid leukemia [3].
公司正在销售的产品:
L-丙氨酰-L-谷胺酰胺 98% 10X分子筛 干燥剂用
4-联苯硼酸 98% 蒽 98%
3-溴邻二甲苯 98% 氧化钕 99%
2-甲酸吡啶铬(III) 98% 碳化钨 粉末,99.9% metals basis, <10μm
2,3-环戊烯并吡啶 98% 天青Ⅱ AR
D-环丝氨酸 98% 火棉胶 AR,4-8% in ethanol/diethyl ether
(S)-UFR2709 hydrochloride10mM*1 mL in DMSO 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. N/AC13H18ClNO2
BI 0138329810mM*1mL in DMSO 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 2227549-00-8C19H19Cl2FN2O3S
Cirsimaritin10mM*1mL in DMSO 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 6601-62-3C17H14O6
COR65910mM*1 mL in DMSO 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 544450-68-2C16H16ClNO3S
CNQX10mM (in 1mL DMSO) 5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 115066-14-3C9H4N4O4
传真号码:021-39596320 021-39921927
QQ: 3004918891 3004905818 3004901493 移动电话:18321818584 15026555973 地址:上海松江新砖公路1155号
产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!