性能参数 |
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产品名称 |
Se-Aspirin |
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规格 |
1mg 5mg 10mg 50mg |
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货号 |
GOY-Y2939 |
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含量 |
>98.00% |
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CAS |
1850293-95-6 |
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别名 |
Selenium-acetylsalicylic Acid |
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化学名 |
selenocyanic acid, 2-[[2-(acetyloxy)benzoyl]amino]ethyl ester |
分子式 |
C12H12N2O3Se |
分子量 |
分子量 311.2 |
溶解度 |
≤10mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide |
储存条件 |
Store at -20°C |
General tips |
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用途 |
仅供科研 |
价格 |
电询 |
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详细内容 |
Se-Aspirin is a novel selenium-nonsteroidal anti-inflammatory drug (Se-NSAID) [1]. NSAIDs have demonstrated intestinal antineoplastic effects in various animal intestinal cancer models. Selenium (Se) compounds have attracted a vast interest as promising chemo-preventive agents. Several epidemiological studies have reported an inverse association between the nutritional Se status and cancer risk. Se functioned as chemo-preventive agent for cancer therapy in the past few years. Se-Aspirin was a hybrid of selenium and a nonsteroidal anti-inflammatory drug. t Se-Aspirin reduced the viability of different cancer cell lines, particularly colorectal cancer (CRC) cells with the IC50 value of 3.4 μM. Se-Aspirin inhibited the cell cycle in G1 and G2/M phases and induced apoptosis by activating caspase 3/7 and PARP cleavage. Long-term exposure to Se-Aspirin has been reported to cause an increase in intracellular reactive oxygen species levels in CRC cells [1]. |
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