Se-Methylselenocysteine
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产品名称:
Se-Methylselenocysteine
产品型号:
GOY-Y2938
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
Se-MethylselenocysteineH2O: 83.33 mg/mL (457.66 mM)
Se-Methylselenocysteine
的详细介绍
性能参数
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产品名称
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Se-Methylselenocysteine
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规格
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5mg 10mg 50mg 100mg
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货号
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GOY-Y2938
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含量
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>98.00%
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CAS
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26046-90-2
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别名
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N/A
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化学名
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N/A
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分子式
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C4H9NO2Se
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分子量
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分子量 182.08
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溶解度
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H2O: 83.33 mg/mL (457.66 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Se-Methylselenocysteine, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine is orally bioavailable, and induces apoptosis[1][2].
Se-Methylselenocysteine (100-400 μM; 3 days) induces apoptosis in SKOV-33 cells[1].Se-Methylselenocysteine (100-400 μM; 3 days) induces caspase-3 mediated apoptosis[1]. Apoptosis Analysis[1] Cell Line: SKOV-3 cells
Se-Methylselenocysteine (0.2 mg/mouse; p.o.; daily for 14 days) potentiates the antitumour activity of CDDP and Cyclophosphamide in nude mice bearing human FaDu and A253 head and neck xenografts[2].Alzheimer's disease (AD) mice are treats with Se-Methylselenocysteine (0.75 mg/kg BW per day) in their drinking water for 10 months. Se-Methylselenocysteine reduces oxidative stress and neuro-inflammation; Se-Methylselenocysteine modulates the distribution and levels of several metal ions; Se-Methylselenocysteine decreases amyloid-β peptide (Aβ) generation by inhibiting the expression of its precursor protein APP and β-secretase (BACE1), and attenuates tau hyperphosphorylation and neurofibrillary tangles (NFT) formation via promoting protein phosphatase 2A (PP2A) activity, thereby preserving synaptic proteins and neuron activities and finally improving spatial learning and memory deficits in AD model mice[3]. Animal Model: Female athymic nude mice (bearing human A253 and FaDu squamous cell carcinoma xenografts)[2]
[1]. Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182(1):83-92. [2]. Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110(7):1733-43. [3]. Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62(12):e1800107.
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