性能参数
产品名称
SGI-1776 free base
规格
10mM (in 1mL DMSO) 5mg 10mg 50mg
货号
GOY-Y2937
含量
>98.00%
CAS
1025065-69-3
别名
SGI1776,SGI 1776
化学名
N-[(1-methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amine
分子式
C20H22F3N5O
分子量
分子量 405.42
溶解度
≥ 40.5 mg/mL in DMSO, ≥ 101 mg/mL in EtOH
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
SGI-1776 free base, N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine, is a potent ATP-competitive inhibitor of the serine/threonine family of Pim kinase, an enzyme regulating cell survival. Through extensive biomedical characterization, SGI-1776 exhibits specificity to the three isoforms of the Pim family, including Pim-1, Pim-2, and Pim-3. According to preliminary results from studies treating prostate cancer cells, SGI-1776 dose-dependently reduces phosphorylation of known Pim kinase substrates involved in cell cycle progression and apotosis (p21Cip1/WAF1 and Bad), compromises overall cell viability by inducing G1 cell cycle arrest and triggering apoptosis, and reduces cell viability in a multidrug resistance 1 (MDR1) protein based taxane-refractory prostate cancer cell line.
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!