性能参数
产品名称
Nutlin-3a chiral
规格
0mM (in 1mL DMSO) 10mg 50mg 200mg
货号
GOY-Y2895
含量
>98.00%
CAS
675576-98-4
别名
Nutlin-3a;Nutlin 3a
化学名
4-[(4S,5R)-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one
分子式
C30H30Cl2N4O4
分子量
分子量 581.49
溶解度
≥ 29.0745 mg/mL in DMSO, ≥ 104.4 mg/mL in EtOH
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Nutlin-3 is a small-molecule inhibitor of MDM2 (mouse double minute 2) with IC50 value of 0.09μM [1].
Nutlin-3 binds MDM2 in the TP53-bindingpocket, thereby interfering with MDM2-directed TP53 degradation. This has been shown to cause cell cycle arrest, growth inhibitionand apoptosis in both solid tumors and lymphoid neoplasms.In mantle cell lymphoma(MCL), it is reported that Nutlin-3 can inhibit cell growth and activate apoptosis in bothwt-TP53(IC50 of 1 to 10μM) and mt-TP53(IC50 of 22.5μM) cells [2].
Nutlin-3 can also effectcell cycle in gastric cancer cell lines. It induces G1 arrest inMKN-45 and SNU-1 cell lines. In vitro assay shows Nutlin-3can enhance the antitumoreffects of conventional chemotherapeutic agents in several gastric cancer cell lines. And in in vivo assay, Nutlin-3 significantly inhibits the growth of xenograft tumors [3].
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