Maytansinol (Ansamitocin P-0)
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产品名称:
Maytansinol (Ansamitocin P-0)
产品型号:
GOY-Y2870
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-05-04
简单介绍
Maytansinol (Ansamitocin P-0)DMSO : ≥ 35 mg/mL (61.94 mM)
Maytansinol (Ansamitocin P-0)
的详细介绍
性能参数
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产品名称
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Maytansinol (Ansamitocin P-0)
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规格
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10mM*1mLinDMSO 5mg 10mg 50mg
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货号
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GOY-Y2870
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含量
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>98.00%
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CAS
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57103-68-1
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别名
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N/A
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化学名
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N/A
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分子式
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C28H37ClN2O8
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分子量
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分子量 565.06
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溶解度
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DMSO : ≥ 35 mg/mL (61.94 mM)
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Maytansinol inhibits microtubule assembly and induces microtubule disassembly in vitro.Target: Microtubule/Tubulinin vitro: Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. Maytansinol reduces the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to drug.
[1]. Edwards A, et al. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul;4(4):496-503.
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