性能参数 |
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产品名称 |
Luteolin |
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规格 |
50mg 100mg 500mg 1g |
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货号 |
GOY-Y2868 |
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含量 |
>98.00% |
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CAS |
491-70-3 |
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别名 |
3',4',5,7-Tetrahydroxyflavone |
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化学名 |
2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one |
分子式 |
C15H10O6 |
分子量 |
分子量 286.24 |
溶解度 |
DMF: 20 mg/ml,DMF:PBS (pH 7.2) (1:5): 1 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml |
储存条件 |
Store at -20°C |
General tips |
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用途 |
仅供科研 |
价格 |
电询 |
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详细内容 |
Luteolin (Luteolol) is a flavanoid with anti-inflammatory, anti-cancer properties, including the induction of apoptosis and cell cycle arrest, and the inhibition of metastasis and angiogenesis, in several cancer cell lines, including human non-small lung cancer cells[1][2]. Luteolin (0-160 μM; 24 hours; NCI-H460 cells) treatment inhibits the viability of NCI-H460 cells in a concentration-dependent manner[1].Luteolin (20-80 μM; 24 hours; NCI-H460 cells) treatment causes an accumulation of cells in the S phase[1].Luteolin (320-580 μM; 48 hours; NCI-H460 cells) treatment induces apoptosis[1].Luteolin (20-80 μM; 24 hours; NCI-H460 cells) treatment increases the protein expression levels of apoptotic regulatory proteins, including the Bax/Bcl-2 ratio, in a concentration-dependent manner, however, only 80 μM Luteolin inhibits the expression of Bad. Luteolin also decreases the expression of Sirt1 in the NCI-H460 cell line in a concentration-dependent manner[1]. Luteolin (10-100?mg/kg; oral gavage; daily; for 12 weeks; male Wistar rats) has an antioxidant effect and can also protect against non-alcoholic steatohepatitis through targeting the pro-inflammatory IL-1 and Il-18 pathways in rats with a high carbohydrate/high fat diet[2]. |
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