性能参数
产品名称
LRRK2-IN-1
规格
10mM (in 1mL DMSO) 10mg 50mg 100mg
货号
GOY-Y2862
含量
>98.00%
CAS
1234480-84-2
别名
LRRK 2-IN-1
化学名
2-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl]anilino]-5,11-dimethylpyrimido[4,5-b][1,4]benzodiazepin-6-one
分子式
C31H38N8O3
分子量
分子量 570.7
溶解度
≥ 28.55mg/mL in DMSO, ≥ 57.2mg/mL in EtOH
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
LRRK2-IN-1 is a potent and selective inhibitor of LRRK2 with IC50 value of 13 nM. [1]
LRRK2 (Leucine-rich repeat kinase 2) is also known dardarin. LRRK2 belongs to the leucine-rich repeat kinase family. LRRK2 mostly located in the cytoplasm, however, it also associates with outer membrane of the mitochondrial. LRRK2 interacts with parkin at the C-terminal R2 RING finger domain. Parkin interacted with LRRK2 at the COR domain. LRRK2 mutation will induce apoptotic cell death of neuroblastoma cells. Expression of LRRK2 mutants has a close relationship with autosomal dominant Parkinson's disease. The LRRK2 Gly2019Ser mutation is a common cause of familial Parkinson's disease. The Gly2019Ser mutation has been proved to cause Parkinson's disease, even though it is a small number of LRRK2 mutations. LRRK2 also has relationship with Crohn's disease by genomewide association studies.
LRRK2-IN-1 dose-dependent inhibit the activity of wild-type and G2019S LRRK2 with IC50 of 0.17 and 0.04μM respectively in HEK293 cells stably expressing GFP tagged wild-type or mutated LRRK2.[2] LRRK2-IN-1 inhibits the activity of both wild-type and G2019S mutant LRRK2 with IC 50 values of 13 nM and 6 nM respectively in vitro enzyme assay with 0.1 mM ATP. LRRK2-IN-1 competed with ATP. LRRK2-IN-1 has a selective profile compared with other 442 diverse kinases and it has no inhibition effect with LRRK1. LRRK2-IN-1 induced endogenous LRRK2 phosphorylation in lymphoblastoid cells. LRRK2-IN-1 also induced Ser910/Ser935 dephosphorylation of LRRK2 in mice kidney at 100 mg/kg.[1]
公司正在销售的产品:
环己硫醇 98% 甲醇中正十六烷标准溶液 1000μg/ml
邻苯二酚 AR,99.0% 三聚氰酸 98%
正癸烷 standard for GC, ≥99.5% (GC) 三聚氰酸 分析标准品, ≥99.0% (HPLC)
正癸烷 99% 乙基汞标准溶液 10μg/ml,溶剂:甲苯
正癸烷 98% 红外光度法测油标准溶液每套含3瓶
正癸烷 分析标准品,≥99.8% (GC) 正十六烷标准溶液1000mg/L,溶剂:四氯化碳
Congo Red50mg>98.00%Cas No. 573-58-0C32H22N6Na2O6S2
Conantokin-T500μg>98.00%Cas No. 127476-26-0C110H175N31O45S
Conantokin G500μg>98.00%Cas No. 93438-65-4C88H138N26O44
Cyfluthrin100 mg>98.00%Cas No. 68359-37-5C22H18Cl2FNO3
Darodipine (PY 108-068)1mg>98.00%Cas No. 72803-02-2C19H21N3O5
D-CPP-ene10mg>98.00%Cas No. 117414-74-1C8H15N2O5P
DHBP dibromide100mg>98.00%Cas No. 6159-05-3C24H38Br2N2
传真号码:021-39596320 021-39921927
QQ: 3004918891 3004905818 3004901493 移动电话:18321818584 15026555973 地址:上海松江新砖公路1155号
产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!