性能参数
产品名称
VK3-OCH3
规格
5mg 10mg 50mg
货号
GOY-Y2854
含量
>98.00%
CAS
255906-59-3
别名
N/A
化学名
分子式
C14H14O3S
分子量
分子量 262.3
溶解度
DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 25 mg/ml,Ethanol: 5 mg/ml
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
VK3-OCH3 is an analog of vitamin K3 that that has antiproliferative activities in vitro. It preferentially decreases proliferation of IMR-32, LA-N-1, NB-39, and SK-N-SH neuroblastoma cells (IC50s = 2.43, 1.55, 10.69, and 3.45 μM, respectively) compared with non-cancerous HUVEC and HDF cells (IC50s = 26.24 and 87.11 μM, respectively). It increases heme oxygenase-1 (HO-1) and caveolin-1 levels, induces apoptosis, and halts the cell cycle at the G2/M phase in IMR-32 cells. VK3-OCH3 also inhibits protein-tyrosine phosphorylase (PTPase) activity (IC50 = 57.2 μM in a cell-free assay), induces protein-tyrosine phosphorylation in Hep3B hepatoma cells when used at a concentration of 50 μM, and inhibits the growth of Hep3B cells (IC50 = 8.6 μM).
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!