性能参数
产品名称
Nigericin
规格
5mg 10mg 25mg
货号
GOY-Y2762
含量
>98.00%
CAS
28380-24-7
别名
N/A
化学名
分子式
C40H68O11
分子量
分子量 724.96
溶解度
1.2mg/mL in DMF, 20mg/mL in Ethanol
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes[1].Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner[2]. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis[3].
[1]. Zotova L, et al. Novel components of an active mitochondrial K(+)/H(+) exchange. J Biol Chem. 2010 May 7;285(19):14399-414. [2]. Mariathasan S, et al.Cryopyrin activates the inflammasome in response to toxins and ATP.Nature. 2006 Mar 9;440(7081):228-32. [3]. Bissinger R, et al. Triggering of Suicidal Erythrocyte Death by the Antibiotic Ionophore Nigericin. Basic Clin Pharmacol Toxicol. 2016 May;118(5):381-9.
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