Lysophosphatidylcholines
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产品名称:
Lysophosphatidylcholines
产品型号:
GOY-Y2737
产品展商:
谷研
产品文档:
无相关文档
发布时间:2023-04-28
简单介绍
LysophosphatidylcholinesSoluble in 2:1 solution of Chloroform : Methanol
Lysophosphatidylcholines
的详细介绍
性能参数
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产品名称
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Lysophosphatidylcholines
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规格
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10mg 25mg 50mg
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货号
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GOY-Y2737
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含量
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>98.00%
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CAS
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9008-30-4
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别名
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?Lyso-Lecithins (egg)
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化学名
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N/A
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分子式
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C24H50NO7P (for palmitoyl)
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分子量
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分子量 495.6
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溶解度
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Soluble in 2:1 solution of Chloroform : Methanol
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储存条件
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Store at -20°C
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General tips
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用途
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仅供科研
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价格
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电询
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详细内容
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Lysophosphatidylcholines are produced by hydrolysis of the fatty acid of phosphatidylcholine at either the sn-1 or sn-2 position by phospholipase A2 (PLA2) or by lecithin-cholesterol acyltranferase (LCAT), which transfers the fatty acid to cholesterol. [1] Lysophosphatidylcholine has effects on a variety of cell types, including smooth muscle cells, endothelial cells, T lymphocytes, monocytes, and macrophages among others. It is a major phospholipid component of oxidized low-density lipoprotein (ox-LDL), and it accumulates in animal models of atherosclerosis. Lysophosphatidylcholine also has pro-inflammatory properties through its activation and modulation of various signaling pathways, including the ERK pathway as well as through protein tyrosine kinase and G protein-coupled receptor (GPCR) signal transduction. It is released from apoptotic cells in vitro following caspase-3 activation of the calcium-independent PLA2 and acts as a chemoattractant for monocytes.[2] Lysophosphatidylcholine (2 ul, 1%) injected into the caudal cerebellar peduncle of rats induces demyelination of axons in vivo, which are extensively remyelinated by oligodendrocytes six weeks following injection. [3] Lysophosphatidylcholines (egg) is a mixture of lysophosphatidylcholines isolated from chicken egg that has a fatty acid of variable chain length acylated to the sn-1 or sn-2 position.
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