性能参数
产品名称
Tubulysin C
规格
1mg 5mg
货号
GOY-Y2724
含量
>98.00%
CAS
205304-88-7
别名
N/A
化学名
分子式
C41H61N5O10S
分子量
分子量 816.02
溶解度
Soluble in DMSO
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Tubulysin C is a highly cytotoxic peptide isolated from the myxobacterial species Archangium geophyra and Angiococcus disciformis. Tubulysin displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the lower nanomolar range[1]. Tubulysin C is a cytotoxic activity tubulysin which inhibits tubulin polymerization and leads to cell cycle arrest and apoptosis[2].
[1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12. [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!