性能参数 |
|||
产品名称 |
TAME |
||
规格 |
50mg 200mg |
||
货号 |
GOY-Y2707 |
||
含量 |
>98.00% |
||
CAS |
901-47-3 |
||
别名 |
N/A |
|
|
化学名 |
methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate |
分子式 |
C14H22N4O4S |
分子量 |
分子量 342.41 |
溶解度 |
≥ 17.1mg/mL in DMSO |
储存条件 |
Store at -20°C |
General tips |
|
用途 |
仅供科研 |
价格 |
电询 |
|
|||
详细内容 |
TAME (Tosyl-L-Arginine Methyl Ester) is a small molecule APC (Anaphase-promoting complex/cyclosome) inhibitor with IC50 of 12 μM in Xenopus oocytes. [1] APC is an ubiquitin ligase with multi subunits. It ubiquitinates substrates (e.g. cyclin B1 and secrin) and make them the targets for degradation with 26s proteasome, resulting in initiation of anaphase and mitotic exit. [2] In mitotic Xenopus oocytes, TAME competes with the Cdc20 C-terminal IR-tail for APC binding to inhibit APC-dependent proteolysis. [3] TAME also stabilizes cyclin B1via terminating ubiquitination prenaturally. It slows the unmodified cyclin B1 initial ubiquitination. In the presence of TAME, ubiquitinated cyclin B1 is not able to promote Cdc20 binding to the APC. [4] |
公司正在销售的产品:
磷酸二氢钾 99.99% metals basis 1,2-乙二硫醇 97% 磷酸三钾 AR 溴代异辛烷 99% 邻苯二甲酸 CP,99.0% 薄荷酰胺 98% 邻苯二甲酸 ACS, ≥99.5% 1-己硫醇 96% 邻苯二甲酸 AR,99.5% 正庚硫醇 98% 邻苯二甲酸 standard for GC, ≥99.5% (GC) 1,6-己二硫醇 97% |
Sofosbuvir impurity K10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 1496552-51-2C22H29ClN3O9P Sofosbuvir impurity I10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. N/AC21H27FN3O9P Sofosbuvir impurity H10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. N/AC29H33FN3O10P Sofosbuvir impurity G10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 1337482-15-1C22H29FN3O9P Sofosbuvir impurity F10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. 1337482-17-3C34H45FN4O13P2 Sofosbuvir impurity E10mM*1mLinDMSO 1mg 5mg>98.00%Cas No. N/AC22H29FN3O9P |
传真号码:021-39596320 021-39921927
QQ: 3004918891 3004905818 3004901493
移动电话:18321818584 15026555973
地址:上海松江新砖公路1155号
产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!