性能参数
产品名称
Streptochlorin
规格
1mg 5mg
货号
GOY-Y2705
含量
>98.00%
CAS
120191-51-7
别名
N/A
化学名
分子式
C11H7ClN2O
分子量
分子量 218.6
溶解度
DMSO: soluble,Methanol: soluble
储存条件
Store at -20°C
General tips
用途
仅供科研
价格
电询
详细内容
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the production of reactive oxygen species (ROS) in, Hep3B human hepatocellular carcinoma cells. It does not induce cytotoxicity in RBL-2H3 mast cells at concentrations up to 100 μM. Streptochlorin prevents degranulation in antigen-stimulated mast cells, as well as inhibits Syk kinase and the Src family kinases LYN and Fyn and reduces the secretion of TNF-α and IL-4 induced by dinitrophenyl-human serum album (DNP-HSA) in RBL-2H3 mast cells. It also decreases swelling and reduces scratching behavior in a mouse model of allergic dermatitis induced by dinitrofluorobenzene (DNFB).
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产品均为实验试剂,仅供科研实验使用,非药品、非食品、不可用于动物及人体!