性能参数

产品名称

PD 166285 dihydrochloride

规格

1 mg 10 mg

货号

GOY-Y2651

 含量

>98.00%

CAS

212391-63-4

别名

N/A

化学名

N/A

分子式

C26H27Cl2N5O2.2HCl

分子量

分子量 585.35

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Potent inhibitor of the tyrosine kinases c-Src, fibroblast growth factor receptor 1 (FGFR1), and platelet-derived growth factor receptor β (PDGFRβ) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). Also inhibits the checkpoint kinases Wee1 and Myt1; abolishes Cdc2 phosphorylation in numerous tumor cell lines and abrogates the G2 checkpoint.

Panek et al (1997) In vitro pharmacological characterization of PD 166285, a new nanomolar potent and broadly active protein tyrosine kinase inhibitor. J.Pharmacol.Exp.Ther. 283 1433 PMID:9400019 |Wang et al (2001) Radiosensitization of p53 mutant cells by PD0166285, a novel G2 checkpoint abrogator. Cancer Res. 61 8211 PMID:11719452 |Hashimoto et al (2006) Cell cycle regulation by the Wee1 inhibitor PD0166285, Pyrido [2,3-d] pyimidine, in the B16 mouse melanoma cell line. BMC Cancer 6 292 PMID:17177986

氧化铜 99.9% metals basis，10μm  杀螟硫磷标准溶液 1.00mg/ml（剧毒品）

氧化铜 40nm 球形，99.5%  倍硫磷标准溶液 1.00mg/ml

三氧化铬 ACS  甲氰菊酯 分析标准品，99.9% （剧毒品）

硝酸钴,六水 AR，99%  氟胺氰菊酯标准溶液 1.00mg/ml

硝酸钴,六水 CP ，97%  苯丁锡 分析标准品，99.5%

硝酸钴,六水 99.99% metals basis  苯线磷 分析标准品，99.6%（剧毒品）

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N-Demethylvancomycin (hydrochloride)5 mg 10 mg 25 mg 50 mg>95.00%Cas No. 198774-23-1C65H73Cl2N9O24·XHCl

N-cis-tetradec-9Z-enoyl-L-Homoserine lactone5mg 10mg 25mg 50mg>95.00%Cas No. 1675245-06-3C18H31NO3

N-cis-octadec-9Z-enoyl-L-Homoserine lactone5mg 10mg 25mg 50mg>95.00%Cas No. 1400974-23-3C22H39NO3

Nitrofurantoin-13C3500μg 1mg 5mg 10mg>95.00%Cas No. 1217226-46-4C5[13C]3H6N4O5

Norvancomycin hydrochloride5mg 10mM*1mL in Water 50mg 100mg>95.00%Cas No. 213997-73-0C65H74Cl3N9O24

Purity: >99.00%