性能参数

产品名称

Nitroaspirin

规格

1mg 5mg

货号

GOY-Y2642

 含量

>98.00%

CAS

175033-36-0

别名

N/A

化学名

N/A

分子式

C16H13NO7

分子量

分子量 331.28

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4]. COX-1

[1]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8. [2]. Bertuglia S, et al. Antioxidant activity of nitro derivative of aspirin against ischemia-reperfusion in hamster cheekpouch microcirculation. Am J Physiol Gastrointest Liver Physiol. 2004 Mar;286(3):G437-43. [3]. Corazzi T, et al. Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. [4]. Selvendiran K, et al. NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle. 2008 Jan 1;7(1):81-8.

硫酸镉 ACS  乐果标准溶液 1.00mg/mL，基体：甲醇

钙黄绿素 AR  二嗪磷标准溶液 1.00mg/ml

结晶紫 ACS, ≥90.0%  三氯杀螨醇标准溶液 1.00mg/ml

无水氯化钙 99.99% metals basis  1，1-二氯乙烯标准溶液 0.800mg/ml，基体：甲醇

乙酸钴，四水 99.9% metals basis  2,5-二硝基氯苯标准溶液1.00mg/ml，溶剂：甲醇

乙酸钴，四水 99.999% metals basis  敌敌畏标准溶液 99.8&micr?

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