性能参数

产品名称

Nec-4

规格

250mg 500mg

货号

GOY-Y2640

 含量

>98.00%

CAS

1041644-43-2

别名

N/A

化学名

N/A

分子式

C15H13ClFN3O

分子量

分子量 305.73

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.

Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.

[1]. Maki JL, et al. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15;427(2):164-74.

三氧化二钴 AR,99.0%  四氯化碳标准溶液 0.3mg/L,基体:甲醇

乙酸铜 一水合物  99.95% metals basis  四氯化碳标准溶液 0.6mg/L,基体:甲醇

变色酸 AR  盐酸克仑特罗标准溶液 1.01mg/ml,溶剂:甲醇

变色酸 ACS，99%  甲醇中氯丙那林标准溶液 1.05mg/ml

混合甲酚 CP  2，4-二氯酚标准溶液1.00mg/ml，溶剂：甲醇

混合甲酚 99%  2,4-二氯苯氧乙酸标准溶液 1000mg/L，基体：甲醇

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