性能参数

产品名称

Necrostatin-5

规格

5mg 25mg

货号

GOY-Y2639

 含量

>98.00%

CAS

337349-54-9

别名

N/A

化学名

N/A

分子式

C19H17N3O2S2

分子量

分子量 383.5

溶解度

DMSO: 10 mg/ml

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. Serine/threonine kinase activity of the death domain receptor-associated molecule RIP1 is thought to be essential for Fas ligand-induced and tumor necrosis factor-α (TNF-α) induced necrosis. Necrostatin-5 is a selective allosteric inhibitor of RIP1 kinase that prevents the death of TNF-α-treated FADD-deficient Jurkat cells with an EC50 value of 240 nM.

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