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Myricetin

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产品名称: Myricetin
产品型号: GOY-Y2635
产品展商: 谷研
产品文档: 无相关文档
发布时间:2023-04-28

简单介绍

Myricetin≥ 13.5mg/mL in DMSO


Myricetin  的详细介绍

性能参数

产品名称

Myricetin

规格

10mM (in 1mL DMSO) 20mg

货号

GOY-Y2635

 含量

>98.00%

CAS

529-44-2

别名

Cannabiscetin

 

 

化学名

3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)chromen-4-one

分子式

C15H10O8

分子量

分子量 318.24

溶解度

≥ 13.5mg/mL in DMSO

储存条件

 

General tips

 

用途

仅供科研

价格

电询

详细内容

Myricetin is a common plant-derived flavonoid with a wide range of activities including strong anti-oxidant, anticancer, antidiabetic and anti-inflammatory activities.

Myricetin exhibits the scavenging activity towards a number of radicals and ions. It displays poor activity (IC50 value=1.4 mg/mL) in a superoxide dismutase (SOD)-like activity assay[1]. It prevents cancer cell death via apoptosis via regulation of PI3K/Akt and MAPK signalling pathways[2]. Myricetin exhibits antiphotoaging effects by quenching causative free radicals in the skin. Myricetin is able to suppress UVB-induced COX-2 expression in mouse skin epidermal JB6 P+ cells. It inhibits UVB-induced initiation of activator protein-1 and NF-κβ, as well as Fyn kinase activity[1]. Myricetin inhibits viability of SKOV3 ovarian cancer cells in a dose-dependent manner. It induces DNA DSBs and ER stress, which leads to apoptosis in SKOV3 cells[3]. Myricetin inhibits human Hsp70 by more than 80% with IC50 values of 83, 11 and 12 μM, respectively[4].

Treatment of orthotopic pancreatic tumors with myricetin results in tumor regression and decreases metastatic spread[2]. Exposure to 150 μM myricetin causes 14%, 26%, 5% and 49% inhibition of rabbit platelet aggregation, induced by ADP, arachidonic acid, collagen and PAF, respectively[5].

 

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