性能参数

产品名称

MPTP hydrochloride

规格

10mg 50mg

货号

GOY-Y2634

 含量

>98.00%

CAS

23007-85-4

别名

MPTP

化学名

1-methyl-4-phenyl-3,6-dihydro-2H-pyridine;hydrochloride

分子式

C12H16ClN

分子量

分子量 209.72

溶解度

≥ 20.52 mg/mL in DMSO with ultrasonic and warming, ≥ 25.45 mg/mL in EtOH with ultrasonic and warming, ≥ 21 mg/mL in H2O

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson's Disease.

Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].

The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].

硫酸铬钾,十二水 AR  钴标准溶液100?g/ml，基体: 1%硝酸

硫酸铬钾,十二水  CP  氯离子(Cl-)标准溶液 1000μg/mL，基体:水

硫酸铬钾 ACS  氯离子(Cl-)标准溶液 100μg/mL，基体:水

硝酸镉,四水 AR,99%  铈标准溶液 1000μg/ml，基体：10%HNO3

硝酸镉,四水 CP,98.5%  色度标准溶液 500度，溶剂：10％HCl

硝酸镉,四水 ACS  间甲酚标准溶液 0.98mg/ml，基体：甲醇

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