性能参数

产品名称

Methotrexate disodium

规格

100mg 500mg

货号

GOY-Y2628

 含量

>98.00%

CAS

7413-34-5

别名

N/A

化学名

N/A

分子式

C20H20N8Na2O5

分子量

分子量 498.4

溶解度

N/A

储存条件

4°C, away from moisture and light

General tips

用途

仅供科研

价格

电询

详细内容

Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia)[1][2][3].

Methotrexate (Amethopterin) disodium reduces thymus and spleen indices of mice. Methotrexate disodium markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2].Methotrexate (MTX) disodium (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate disodium (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[4].

[1]. Tian H, et al. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis. 2007;65(3):168-73. [2]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [3]. Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92. [4]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

氧化钙  99.9% metals basis  铍标准溶液 10μg/ml

硝酸钙,四水  AR,99%  苯标准溶液0.96mg/ml，溶剂：甲醇

硝酸钙,四水  CP,98%  生化需氧量(BOD)标准溶液 1000μg/ml

硝酸钙,四水  ACS  气相色谱仪检定用标准物质（苯-甲苯溶液）5.03mg/ml，基体:甲苯

硝酸钙,四水 SP  五日生化需氧量标准品1000mg/L

硝酸钙,四水 99.98% metals basis  水质生化需氧量标样 浓度范围：61.8-148(mg/L)，分?

L-4-Oxalysine hydrochloride1mg 5mg 10mg 20mg>98.00%Cas No. 118021-35-5C5H13ClN2O3

Lasalocid sodium10 mM * 1 mL in DMSO 5mg 10mg 50mg>98.00%Cas No. 25999-20-6C34H53NaO8

Lawsone5g 10g 25g 100g>98.00%Cas No. 83-72-7C10H6O3

Letermovir5mg 10mg 25mg 50mg>98.00%Cas No. 917389-32-3C29H28F4N4O4

Lersivirine5mg 10mg 50mg 200mg>98.00%Cas No. 473921-12-9C17H18N4O2

Lenampicillin hydrochloride (KBT 1585 hydrochloride)10mM*1mLinDMSO 2mg 5mg 10mg>98.00%Cas No. 80734-02-7C21H24ClN3O7S

Lefamulin acetate10mM (in 1mL DMSO) 5mg 10mg 50mg>98.00%Cas No. 1350636-82-6C30H49NO7S