性能参数

产品名称

Wedelolactone

规格

20mg

货号

GOY-Y2608

 含量

>98.00%

CAS

524-12-9

别名

N/A

化学名

1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one

分子式

C16H10O7

分子量

分子量 314.25

溶解度

DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL,Ethanol: 20 mg/mL

储存条件

Store at 2-8°C

General tips

用途

仅供科研

价格

电询

详细内容

Wedelolactone is an inhibitor of IKK.

IkB kinase (IKK) complex contains the catalytic subunits IKKα and IKKβ, and the regulatory subunit IKKγ/NEMO. IKK, is a kinase critical for activation of NF-κB by mediating phosphorylation and degradation of IκBα. The induction of caspase-11 is an important upstream controlling event in inflammatory response and apoptosis under pathological conditions modulated by upstream NF-κB-mediated transcription[1].

In vitro: In cultured mouse BALB/c 3T3 cells, mouse splenocytes and HeLa cells, wedelolactone (0~100 μM) inhibited LPS-induced caspase-11 expression by inhibiting NF-κB-mediated transcription through the direct inhibition of IKK. Wedelolactone played an potential role in anti-inflammatory therapy to inhibit IL-1β levels in diseases such as rheumatoid arthritis, asthma and septic shock[1].

In vivo: On Swiss albino male mouse skin, IKK inhibition by wedelolactone (10 μM) prevented the induction of NF-κB, perturbed the generation of reactive oxygen species and reactive nitrogen intermediates, blunted the signal transduction that lead to the activation of the early immediate genes, and thereby protected mouse skin from the UVB induced neoplastic transformation, angiotropism and metastatic progression [2].

苯甲酸铵 AR,99.0%  硫酸卷曲霉素  Potency 700 - 1050 μG/mg

苯甲酸铵 CP,98.0%  硫酸链霉素 720 I.U./mg

苯甲酸铵 ACS  硫酸链霉素 分析标准品

重铬酸铵 AR,99.0%  盐酸大观霉素,五水 potency: ≥603 μg/mg

重铬酸铵 CP,99.0%  盐酸万古霉素 USP级,效价: ≥900 μg per mg

重铬酸铵 SP  羧苄青霉素钠 USP级

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