性能参数

产品名称

TPP-1

规格

25 mg

货号

GOY-Y2600

 含量

>98.00%

CAS

2426685-25-6

别名

N/A

化学名

N/A

分子式

C107H150N34O32S2

分子量

分子量 2488.67

溶解度

N/A

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function[1].

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation[1].

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors[1].

硝酸铝,九水 99.99% metals basis  二氢吲哚 99%

硝酸铝 九水合物  ACS, ≥98%  吲哚 CP，>98.5% (GC)

磷酸铝 CP  异喹啉羧酸 98%

草酸铵 AR,99.8%  1-甲基-3-吲哚酸 97%

草酸铵 CP,99.5%  2-甲基吲哚啉 99%

草酸铵 GR,99.8%  吲哚-3-羧酸甲酯 99%

Inz-55mg 10mg 25mg 50mg 100mg>98.00%Cas No. 1585214-21-6C18H14F4N6

IT1t5mg 10mg 25mg 50mg 100mg>98.00%Cas No. 864677-55-4C21H34N4S2

KKL-100 1 2 3 4 5 6 7 8 9 10 1mg 5mg 10mg 50mg>98.00%Cas No. 952849-76-2C14H10BrN3O2S

KIN14081mg 5mg 10mg 50mg 100mg>98.00%Cas No. 1903800-11-2C25H19F2N3O3S

KIN11481mg 5mg 10mg 50mg 100mg>98.00%Cas No. 1428729-56-9C19H11N3OS2

Caspofungin Acetate5mg 10mg 25mg 50mg 100mg 500mg>98.00%Cas No. 179463-17-3C56H96N10O19

Cefcapene pivoxil hydrochloride5mg 10mg 25mg 50mg 100mg 200mg>98.00%Cas No. 147816-23-7C23H30ClN5O8S2