性能参数

产品名称

Thevetiaflavone

规格

5mg

货号

GOY-Y2597

 含量

>98.00%

CAS

29376-68-9

别名

N/A

化学名

N/A

分子式

C16H12O5

分子量

分子量 284.26

溶解度

Soluble in DMSO

储存条件

Store at -20°C

General tips

用途

仅供科研

价格

电询

详细内容

Thevetiaflavone could upregulate the expression of Bcl?2 and downregulate that of Bax and caspase?3. Bcl-2 Bax Caspase-3

Thevetiaflavone, a natural flavonoid obtained from Wikstroemia indica, could improve cell viability and suppresses the leakage of lactate dehydrogenase from the cytoplasm. Further investigation of the mechanisms demonstrated that Thevetiaflavone decreases overproduction of ROS and ameliorates ROS?mediated mitochondrial dysfunction, including collapse of mitochondrial membrane potential and mitochondrial permeability transition pore opening. Thevetiaflavone reduces the intracellular Ca2+ level, which is closely associated with mitochondrial function and interplays with ROS. Furthermore, Thevetiaflavone inhibits apoptosis in PC12 cells through upregulating the expression of Bcl?2 and downregulating that of Bax and caspase?3 in addition to increasing the activity of caspase?3. These results further indicate the protective effects of thevetiaflavone in vivo and its application in the clinic[1].

[1]. Yao H, et al. Thevetiaflavone from Wikstroemia indica ameliorates PC12 cells injury induced by OGD/R via improving ROS?mediated mitochondrial dysfunction. Mol Med Rep. 2017 Dec;16(6):9197-9202.

硫酸铝铵 GR  2-苯并咪唑基乙腈 97%

硫酸铝铵 AR,99.5%  5-溴-7-硝基二氢吲哚 98%

硫酸铝铵 CP,99.0%  5-溴代吲哚 98%

碳酸铵 AR  4-溴吲哚 98%

碳酸铵 CP  5-氰基吲哚 99%

碳酸铵 99.999% metals basis  5-氯-1,3,3-**基-2-亚甲基吲哚啉 90%

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